The 2016 FAO-CIHEAM joint edition of Mediterra offers an innovative and prospective approach to the issues of triple waste reduction including agricultural losses, waste of natural resources, and waste of knowledge and know-how. This Report features a collection of shared expertise and local experiences in the Mediterranean region. It provides the keys to understanding and presents solutions for action targeting policy-makers, development operators, professionals, and researchers. Agriculture and food security are two major global challenges. Situated at the heart of the new Sustainable Development Goals (SDGs), they raise several strategic issues for countries and international cooperation. ‘Produce more and better’, such is the equation to help address the challenges related to population growth, changing consumption patterns and scarcity of natural and financial resources. In this context, the reduction of agricultural losses and food waste has become a priority.